Control of blood flow in the cat spinal cord.

نویسندگان

  • O U Scremin
  • E E Decima
چکیده

Spinal cord blood flow (SCBF) and the effect of end-tidal CO2 concentration (ETCO2) on SCBF (CO2 reactivity) were studied in the lumbar spinal cord of cats by means of the hydrogen-clearance technique Hydrogen gas was administered by inhalation, and its level in spinal cord tissue was estimated amperometrically with small (75 micrometers) platinum electrodes. The average SCBF's at normocapnia (ETCO2 = 4%) of the ventral horn gray matter and of the white matter at several locations were 43.2 and 16.2 ml . 100 gm-1 . min-1, respectively. For gray and white matter, the values of CO2 reactivity, estimated by the coefficient of the regression of SCBF (ml . 100 gm-1 . min-1) on ETCO2 (ml . 100 ml-1) were 11.6 and 2.1, respectively. No differences in SCBF or CO2 reactivity were observed between intact animals kept under N2O-O2 ventilation and decerebrated animals with no anesthesia. After an acute spinal section, ventral horn SCBF and CO2 reactivity (measured eight segments below the cordotomy) were not altered, in spite of the profound neural depression present (that is, spinal shock). Orthodromic (dorsal root) stimulation of the ventral horn neurons induced an average increase in blood flow of 128% above control values. Antidromic (ventral root) motoneuron activation failed to produce any significant changes in ventral horn blood flow.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparative studies of regional CNS blood flow autoregulation and responses to CO2 in the cat. Effects of altering arterial blood pressure and PaCO2 on rCBF of cerebrum, cerebellum, and spinal cord.

Autoregulation and CO2 responses were investigated concurrently in cerebrum, cerebellum, and spinal cord of 19 cats by means of hydrogen clearance. Under ketamine and nitrous oxide anesthesia at normal systemic mean arterial blood pressure (MABP 123 +/- 18.4 mmHg, mean +/- standard deviation) blood flow was 86 +/- 30.0 ml/100 g/min in the cerebrum, 48 +/- 13.6 ml/100 g/min in the cerebellum, an...

متن کامل

Comparative studies of regional CNS blood flow and evoked potentials in the cat. Effects of hypotensive ischemia on somatosensory evoked potentials in cerebral cortex and spinal cord.

Functional resistance to graded hypotensive ischemia of various segments of the somatosensory pathway was determined in anesthetized cats by repeated concurrent recordings of regional blood flow measured by hydrogen clearance, and evoked potentials (EPs), of dorsal horn of lumbar spinal cord and cerebral cortex. During normal resting CNS blood flow (CBF), there were significant successive reduc...

متن کامل

Regulation of total and regional spinal cord blood flow.

Studies of the regulation of total spinal cord blood flow have been limited by methodology. Total flow has been difficult to measure and flow to the gray and white matter within the cord has not been previously assessed. We have used labeled microspheres to measure blood flow in the spinal cord. Our purpose was to examine the effects of several physiological stimuli on the regulation of blood f...

متن کامل

O2: Flaxseed Reduces Proinflammatory Factors IL-1β, IL-18 and TNF-α in Injured Spinal Cord Rat Model

The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary mechanisms of injury. Secondary injury mechanisms include inflammation, oxidative stress. The secondary inflammation of spinal cord tissue after SCI was critical for the survival of motor neuron and functional recovery. Flaxseed is a rich source of lignan phytoestrogen, α-linolenic acid. Flaxseed has rema...

متن کامل

Correlation of Oxidative and Antioxidative Processes in the Blood of Patients with Cervical Spinal Cord Injury

The effect of cervical spinal cord injury (CSCI) on oxidative stress parameters was assessed. The study was conducted in 42 patients with CSCI (studied group), 15 patients with cerebral concussion, without CSCI (Control II), and 30 healthy volunteers (Control I). Blood was taken from the basilic vein: before and seven days after the spinal cord decompression surgery (mean time from CSCI to surg...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of neurosurgery

دوره 58 5  شماره 

صفحات  -

تاریخ انتشار 1983